Personalized drug therapy with pharmacogenetics. Part 1: Pharmacokinetics.
نویسنده
چکیده
منابع مشابه
I-33: Pharmacogenetics of Reproductive Medicine
Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. Inter-individual genetic differences can have significant roles in determining an individual’s susceptibility to ADRs. The rapid development of techniques in the area of genome analysis has put the scientific community in a power position and facilitated identification of new pharmacogenomic biomarkers that ...
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Busulfan- and treosulfan-based conditionings are the cornerstone of pediatric allogeneic hematopoietic stem cell transplantation (HSCT). Although both drugs are alkylating agents, their mechanisms of action, pharmacokinetics (PK) and toxicity profiles are different. Experience with busulfan in pediatric HSCT is broad and the knowledge on the pharmacodynamics (PD), PK and, to a lesser extent, ph...
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Pharmacogenetics and pharmacogenomics is an emerging science that has a great application in drug development and therapeutics. It improves individualized therapy and gives crucial approach individuals with variability in drug response due to heredity thereby promotes personalized medicine. Pharmacogenomics intends to develop rational means of optimizing drug therapy, with respect to the patien...
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Rapid technological advances in genetics have created conceptual chaos regarding the genetics of drug response. Terms for differing concepts are used interchangeably: pharmacogenetics with pharmacogenomics, personalized medicine with personalized prescription. Biomarker has many definitions. The author prefers the concept of personalized prescription and uses it with implications beyond pharmac...
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عنوان ژورنال:
- Journal of psychosocial nursing and mental health services
دوره 44 1 شماره
صفحات -
تاریخ انتشار 2006